The condition is known as Diamond Blackfan Anaemia and the five-year-old has relied on donors to keep him alive ever since he was a baby.
Archie needs blood every three weeks and he is due to receive his 59th transfusion next week.
His mum Vicky is now urging people to book in to give blood, with appointments even available on Christmas Eve and Boxing Day.
The 38-year-old, who lives in Harrogate with her husband Dean and their seven-year-old daughter Holly, said blood is Archie’s lifeline.
Vicky said: “Archie is a typical five-year-old. He’s a massive fan of superheroes and a real livewire. To look at him you’d never know there was anything wrong.
“Archie knows his bones don’t make blood so he needs blood from other people. Before a transfusion he is unsettled and bad tempered, but once he has that good blood in him the happy, lively little boy who loves cuddles is back. Blood changes everything for Archie – It is literally his lifeline.”
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